Pseudoexfoliation syndrome (PXF) is a condition in which tiny flakes of protein build up in the body and settle in the front of the eye — on the iris, lens and drainage structures. When these flakes clog the drainage system, the pressure rises and pseudoexfoliation glaucoma develops.
It is not the same as 'true exfoliation', which is caused by heat or infrared exposure. PXF is rarely seen before age 50 and becomes more common with age. It is more common in women and is most often seen in Scandinavian populations, though it can occur in all ethnic groups.
Pseudoexfoliation glaucoma often progresses faster than primary open-angle glaucoma and the eye pressure can be harder to control. It is frequently linked to more advanced optic nerve damage and visual field loss. It can also make cataract surgery more difficult because the material weakens the structures that support the lens, so specialist experience is important.